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          2004

1. Min Su Han, Dong Ju Oh, and Dong H. Kim.  " Inhibiton of a-Chymotrypsin with Thiol-bearing Substrate Analogs in the Presence of Zinc Ion".Bioorg. Med. Chem. Lett. 2004, 14, 701-705.

2. Jung Dae Park and Dong H. Kim. "Sulfamide derivatives as transition state analogue inhibitors for carboxypeptidase A". Bioorg. Med. Chem. 2004, In Press.

3. Min Su Han, Sang Oh Jung, Mahn-Joo Kim, and Dong H. Kim "Fluorometric Assay Protocol for Protease-Catalyzed Transesterification Reactions in Organic Solvents". J. Org. Chem. 2004, In Press

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8.  Lee, H. S.; Kim, D. H.. "Synthesis and Evaluation of a,a-Disubstituted-3-mercaptopropanoic Acids as Inhibitors for Carboxypeptidase A and Implications with Respect to Enzyme Inhibitor Design", Bioorg. Med. Chem.2003, 11, 4685-4891.

7.  Jin, J. -Y.; Tian, G. R.; Kim, D. H.. "Optically Active 2-Benzyl-3-methanesulfinylpropanoic Acid:Synthesis and Evaluation as Inhibitors for Carboxypeptidase A", Bioorg. Med. Chem.2003, 11, 4377-4381.

6.  Park, J. D.; Kim, D. H.. "Reversed Hydroxamate-bearing Zinc Protease Inhibitors Mimic High Energy Intermediate along the Enzyme-catalyzed Reaction Pathway", Bioorg. Med. Chem. Lett. 2003, 13, 3161-3166.

5.  Kim, D. H..; Han, M . "Molecular Probe for Selective Detection of Thiols in Water of Neutral pH", Bioorg. Med. Chem. Lett. 2003, 13, 2543-2546.

4. Kim, S. -J.; Kim, D. H.; Park, J.D.; Woo, J. -R.; Jin, Y. Ryu, S.E. "Origin of the Stereospecificity in Binding Hydroxamate of a- ans b-Phenylalanine Methylamide to Thermolysin Revealed by the X-ray Crystallographic Study", Bioorg. Med. Chem. 2003, 11, 2421-2426.

3. Lee, H. S.; Park, J. D.; Kim, D. H.. "Convenient Synthesis of Optically Pure a-Mono and a,a-Disubstituted b-Amino Acids" Bull. Kor. Chem. Soc. 2003, 24, 467-472.

2.  Han, M.; Kim, D. H.. "Visual Detection of AMP and Real-Time Monitoring of Cyclic Nucleotide Phosphodiesterase (PDE) Activity in Neutral Aqueous Solution. Chemosensor-Coupled Assay of PDE and PDE Inhibitors", Bioorg. Med. Chem. Lett. 2003, 13, 1079-1082.

1. Han, M.; Kim, D. H.. "Readily Available Fluoresence Probes for Zinc Ion in Aqueous Solution of Neutral pH", Supramolecular Chem. 2003, 15, 59-64.

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8.  Park, J. D.; Kim, D. H..; Kim, S. -J.; Woo, J. -R.; Ryu, S. E. "Sulfamide-Based Inhibitors for Carboxypeptidase A. Novel Type Transition State Analogue Inhibitors for Zinc Proteases", J. Med. Chem. 2002, 45, 5295-5302. [PDF]

7.  Han, M.; Kim, D. H.. "Naked-Eye Detection of Phosphate Ions in Water at Physiological pH: A Remarkably Selective and Easy-To-Assemble Colorimetric Phosphate-Sensing Probe" Angew. Chem. Int. Ed. 2002, 41, 3809-3811. [PDF]

6.  Chin, J.; Chung, S.; Kim, D. H.. "Synergistic Effect between Metal Coordination and Hydrogen Bonding in Phosphate and Halide Recognition " J. Am. Chem. Soc. 2002, 124, 10948-10949. [PDF]

5.  Kim, D. H..; Park, J.; Chung, S. J.; Park, J. D.; Park, N.; Han, J. H. "Cleavage of b-lactone ring by serine protease. Mechanistic implications" Bioorg. Med. Chem. 2002, 10, 2553-2560. [PDF]

4.  Lee, H. S.; Kim, D. H.. "Alpha-alkylcysteines as Inhibitors for Carboxypeptidase A. Sythnesis, Evaluation, and Implication for Inhibitor Design strategy" Bull. Kor. Chem. Soc. 2002, 23, 593-598. [PDF]

3.  Cho, J. H.; Kim, D. H..; Chung, S. J.; Ha, N.; Oh, B.; Choi, K. Y. "Insight into the Stereochemistry in the Inhibition of Carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: Binding Modes of an Enantiomeric Pair of the Inhibitor to Carboxypeptidase A" Bioorg. Med. Chem. 2002, 10, 2015-2022. [PDF]

2.  Lee, M.; Kim, D. H.."Synthesis and Kinetic Evaluation of Racemic and Optically Active 2-Benxyl-2-methyl-3,4-epoxybutanoic Acid as Irreversible Inactivators for Carboxypeptidase A" Bioorg. Med. Chem. 2002, 10, 913-922. [PDF]

1.  Park, J. D.;Kim, D. H."Cysteine Derivatives as Inhibitors for Carboxypeptidase A: Synthesis and Structure-Activity Relationships", J. Med. Chem. 2002, 45, 911-918. [PDF]

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10.  Park, J.; Kim, D. H. "2-Benzyl-3,4-iminobutanoic Acid as Inhibitor of Carboxypeptidase A", Bioorg. Med. Chem. Lett. 2001, 11, 2967. [PDF]

9.  Lee, M.; Kim, D. H. "Inhibition of carboxypeptidase A with beta-lactone-bearing phenylalanine. Design, synthesis, and stereochemistry-dependent inhibition mode", Bull. Kor. Chem. Soc. 2001, 22, 1236. [PDF]

8.  Chung S. J.; Chung, S.; Lee, H. S.; Kim, E.; Oh, K. S.; Choi, H. S.; Kim, K. S.; Kim, Y. J.; Hahn, J. H.; Kim, D. H. "Mechanistic Insight into the Inactivation of Carboxypeptidase A by a-Benzyl-2-oxo-1,3-oxazolidine-4-acetic Acid, a Novel Type of Irreversible Inhibitor for Carboxypeptidase A with No Stereospecificity", J. Org. Chem. 2001, 66, 6462.[PDF]

7.  Kim, D. H. "Origin of Chiral Pharmacology: Stereochemistry in Metalloprotease Inhibition", Mini Rev. Med.Chem. 2001, 1, 155. [PDF]

6.  Park, J.; Tian, G. R.; Kim, D. H. "Synthesis of Optically Active 2-Alkyl-3,4-iminobutanoic Acids. b-Amino Acids Containing an Aziridine Heterocycle", J. Org. Chem. 2001, 66, 3696.[PDF]

5.  Cho, J. H.; Kim, D. H.; Kim, D.; Lee, K. J.; Choi, K. Y. "The Role of Tyr248 Probed by Mutant Bovine Carboxypeptidase A: Insight into the Catalytic Mechanism of Carboxypeptidase A", Biochemistry 2001, 40, 10197.[PDF]

4.  Han, M.; Kim, D. H. "Effect of Zinc Ion on the Inhibition of Carboxypeptidase A by Imidazole-Bearing Substrate Analogues", Bioorg. Med. Chem. Lett. 2001, 11, 1425.[PDF]

3.  Park, J. D.; Lee, K. J.; Kim, D. H. "A New Inhibitor Design Strategy for Carboxypeptidase A as Exemplified by N-(2-Chloroethyl)-N-methylphenylalanine", Bioorg. Med. Chem. 2001, 9, 237.[PDF]

2.  Chung S. J.; Kim, D. H. "N-(Hydroxyaminocarbonyl)phenylalanine: A Novel Class of Inhibitor for Carboxypeptidase A", Bioorg. Med. Chem. 2001, 9, 185.[PDF]

1.  Kim, D. H.; Mobashery, S. "Mechanism-Based Inhibition of Zinc Proteases", Curr. Med. Chem. 2001, 8, 959. [PDF]

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3.  Han, M. S.; Ryu, C. H.; Chung, S. J.; Kim, D. H. "A Novel Strategy for Designing Irreversible Inhibitors of Metalloproteases: Acetals as Latent Electrophiles That Interact with Catalytic Nucleophile at the Active Site", Org. Lett. 2000, 20, 3149-3152. [PDF]

2.  Lee, M. J.; Kim, D. H. "Hippurylmethylphenylalanine and Hippuryl methyl phenyllactic Acid as Substrates for Carboxypeptidase A.Syntheses, Kinetic Evaluation and Mechanistic Implicationrigin of Chiral Pharmacology: Stereochemistry in Metalloprotease Inhibition", Bioorg. Med. Chem. 2000, 8, 815-823.[PDF]

1.  Kim, D. H.; Lee, S. S. "Origin of Rate-Acceleration in Ester Hydrolysis with Metalloprotease Mimics", Bioorg. Med. Chem. 2000, 8, 647-652. [PDF]

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5.  Kim, D. H.; Chung, S. M. "Stereochemistry in enzyme inhibition: synthesis and evaluation of enantiomerically pure 2-benzyl-3-formylpropanoic acids as inhibitors of carboxypeptidase A", Tetrahedron: Asymmetry 1999, 10, 3769-3776. [PDF]

4.  Chin, J.; Lee, S. S.; Lee, Park, S. S.; Kim, D. H. "A metal complex that binds a-amino acids with high and predictable stereospecificity", Nature 1999, 401, 254-257.[PDF]

3.  Kim, D. H.; Jin, Y. H. "First Hydroxamate Inhibitors for Carboxypeptidase A. N-Acyl-N-hydroxy -b-Phenylalanines.", Bioorg. Med. Chem. Lett. 1999, 9, 691-696.[PDF]

2.  Lee, M. J.; Jin, Y. H.; Kim, D. H. "2-Benzyl-2-methylsuccinic Acid as Inhibitor for Carboxypeptidase A. Synthesis and Evaluation", Bioorg. Med. Chem. 1999, 7, 1755-1760.[PDF]

1.  Kim, D. H. "Design of Protease Inhibitors on the Basis of Substrate Stereospecificity ", Biopolymer 1999, 51, 3-8. [PDF]

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6.  Kim, D. H.; Chung, S. J.; Kim, E. J.; Tian, G. R. "Irreversible Inhibition of Zinc-Containing Protease by Oxazolidinone Derivatives. Novel Inactivation Chemistry ",Bioorg. Med. Chem. Lett. 1998, 8, 859-864. [PDF]

5.  Jin, Y. H.; Kim, D. H. "Inhibition Stereochemistry of Hydroxamate inhibitors for Thermolysin",Bioorg. Med. Chem. Lett. 1998, 8, 3515-3518. [PDF]

4.  Lee, K. J.; Kim, D. H. "Detection of Anhydride Intermediate in the Carboxypeptidase A Catalyzed Hydrolysis of a Peptide Substrate by Solid State NMR Spectroscopy and Its Mechanistic Implication", Bioorg. Med. Chem. Lett. 1998, 8, 3379- 3384. [PDF]

3.  Lee, K. J.; Kim, D. H. "Inhibition of Thermolysin With Nitron-Bearing Substrate Analogs: A  New Type of Thermolysin Inhibitors", Bioorg. Med. Chem. Lett. 1998, 8, 323-326. [PDF]

2.  Kim, D. H..; Li, Z. H.; Lee, S. S.; Park, J. I.; Chung, S. J. "A Novel Type of Structurally Simple Nonpeptide Inhibitors for a-Chymotrypsin. Induced-fit Binding of Methyl 2-allyl-3-benzene-propanoate to the S2 Subsite Pocket", Bioorg. Med. Chem. Lett. 1998, 6, 239- 249. [PDF]

1.  Lee, K. J.; Kim, D. H. "Design of Mechanism-Based Carboxypeptidase A Inactivators on the Basis of the X-ray Crystal Structure and Catalytic Reaction Pathway", Bioorg. Med. Chem. 1998, 6, 1613-1622. [PDF]

 

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